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REPARTI Seminars


The CerVIM Seminars, Université Laval are held on Fridays at 11:30 a.m.
Please see the program for more details.

 

 

 

REPARTI

MIVIM

Jun 5 2019 11:00AM

Dr. Jean-Marc Schwartz
Division of Evolution & Genomic Sciences
The University of Manchester

Computational systems and network-based approaches for the investigation of human diseases



Abstract

Systems and network-based approaches are increasingly used to study dysregulated molecular components in diseases. By modelling the relations between genes/proteins in an integrative manner, we can gain better understanding of the processes involved in disorders and infer their regulators, paving the way for the development of new treatments. In this seminar, we will describe different approaches enabling us to model disease systems. First, we will present Boolean and kinetic models of the action of Herceptin, a drug that is widely used to treat breast cancer but whose effectiveness is hampered by the development of resistance in tumour cells. Next, we will present an integration of network analysis with gene expression (RNA-sequencing) data applied to the study of skeletal diseases, and show how this integration helps to discover new pathways and regulators involved in these disorders.

A biography of Dr. Schwartz is available on the following web site: https://www.research.manchester.ac.uk/portal/jean-marc.schwartz.html


The seminar will be presented at 11:00 a.m. in room PLT-3370.




     
   
   

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